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Conversely, insufflation has a slower onset of action, due to delayed absorption, inducing effects within ~3–4 min and peak experiences within ~35–40 min, resolving within ~60–70 min (24). For example, vaporization induces effects within ~10–15 s and peak experiences within ~2–5 min, resolving within ~25–30 min (6, 22, 23). Nonetheless, MAOIs can induce serotonergic toxicity (19), or ‘serotonin syndrome’, a potentially [...]